Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis
作者： Hui Li , Xiaojun Tang , Qin Liu , Yang Wang
DOI: 10.1007/S00592-012-0400-7
关键词:
摘要: To assess the association between type 2 diabetes and rs10811661 polymorphism, upstream of CDKN2A/B, a literature-based search was conducted to collect data. The pooled OR (odds ratio) 95 % confidence intervals (CI) were used strength polymorphism diabetes. with CI performed for allele contrasts, additive genetic model, dominant model recessive respectively. effect if there heterogeneity studies. Funnel plots predict publication bias. 17 studies 29,990 cases 40,977 controls enrolled in this meta-analysis. Significant found all four models: contrast (OR = 1.21, 1.18-1.24), (OR = 1.51, 1.40-1.63), (OR = 1.37, 1.28-1.47) (OR = 1.25, 1.21-1.29). meta-analysis indicated that significantly associated risk
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