摘要: Publisher Summary This chapter explores the platelet surface receptors involved in adhesion and their structure/function relationships. Platelets contain a wide variety of membrane glycoproteins many that are critical for or aggregation. Studies have pointed to importance von Willebrand factor (vWf)/GPIb axis as at high shear found capillaries larger vessels under atherosclerotic conditions. The glycoprotein (GP) Ib-V-IX complex consists four chains each coded by separate genes present on different chromosomes. GPIb contains GPIba GPIbP linked disulfide bond while GPIX is strongly non-covalently associated 1:1 ratio GPV weakly with 1 :2 ratio. structure vWf also broadly known although details remain be determined. It has been some time A1 domain sites GPIb, collagen, heparin interactions more recent studies sequence mutants, Type IIb Willebrand's disease, effects glycosylation differences animal narrowed down binding site loop formed cysteine bridge neighboring sequences. fact collagen-binding close proximity supports idea conformational changes GPIb-binding probably induced collagen-binding.
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