The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics.
作者： Ishraga E A-Elbasit , Michael Alifrangis , Insaf F Khalil , Ib C Bygbjerg , Emad M Masuadi
关键词:
摘要: Background The Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism. The dhfr dhps gene mutations known to be associated with sulphadoxine/pyrimethamine (SP) resistance.
biomedcentral.com
springer.com
core.ac.uk
paperity.org参考文章(18)
Karen I. Barnes, Nicholas J. White, Population biology and antimalarial resistance: The transmission of antimalarial drug resistance in Plasmodium falciparum. Acta Tropica. ,vol. 94, pp. 230- 240 ,(2005) , 10.1016/J.ACTATROPICA.2005.04.014
J. T. Bousema, L. C. Gouagna, A. M. Meutstege, B. E. Okech, N. I. J. Akim, J. I. Githure, J. C. Beier, R. W. Sauerwein, Treatment failure of pyrimethamine‐sulphadoxine and induction of Plasmodium falciparum gametocytaemia in children in western Kenya Tropical Medicine & International Health. ,vol. 8, pp. 427- 430 ,(2003) , 10.1046/J.1365-3156.2003.01047.X
I HASTINGS, M DONNELLY, The impact of antimalarial drug resistance mutations on parasite fitness, and its implications for the evolution of resistance. Drug Resistance Updates. ,vol. 8, pp. 43- 50 ,(2005) , 10.1016/J.DRUP.2005.03.003
Fabián Méndez, Álvaro Muñoz, Gabriel Carrasquilla, Diana Jurado, Myriam Arévalo-Herrera, Joseph F Cortese, Christopher V Plowe, Determinants of Treatment Response to Sulfadoxine-Pyrimethamine and Subsequent Transmission Potential in Falciparum Malaria American Journal of Epidemiology. ,vol. 156, pp. 230- 238 ,(2002) , 10.1093/AJE/KWF030
Maha E. Osman, Frank P. Mockenhaupt, Ulrich Bienzle, Mustafa I. Elbashir, Hayder A. Giha, Field-based evidence for linkage of mutations associated with chloroquine (pfcrt/pfmdr1) and sulfadoxine-pyrimethamine (pfdhfr/pfdhps) resistance and for the fitness cost of multiple mutations in P. falciparum. Infection, Genetics and Evolution. ,vol. 7, pp. 52- 59 ,(2007) , 10.1016/J.MEEGID.2006.03.008
Jacques Le Bras, Remy Durand, The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum. Fundamental & Clinical Pharmacology. ,vol. 17, pp. 147- 153 ,(2003) , 10.1046/J.1472-8206.2003.00164.X
Lorenz von Seidlein, Musa Jawara, Rosalind Coleman, Tom Doherty, Gijs Walraven, Geoffrey Targett, Parasitaemia and gametocytaemia after treatment with chloroquine, pyrimethamine/sulfadoxine, and pyrimethamine/sulfadoxine combined with artesunate in young Gambians with uncomplicated malaria Tropical Medicine & International Health. ,vol. 6, pp. 92- 98 ,(2001) , 10.1046/J.1365-3156.2001.00683.X
David Walliker, Paul Hunt, Hamza Babiker, Fitness of drug-resistant malaria parasites. Acta Tropica. ,vol. 94, pp. 251- 259 ,(2005) , 10.1016/J.ACTATROPICA.2005.04.005
T. Triglia, J. G. T. Menting, C. Wilson, A. F. Cowman, Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 13944- 13949 ,(1997) , 10.1073/PNAS.94.25.13944
D. S. Peterson, D. Walliker, T. E. Wellems, Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 9114- 9118 ,(1988) , 10.1073/PNAS.85.23.9114