Mapping ‘partially resistant’, ‘fully resistant’, and ‘super resistant’ malaria
作者： Inbarani Naidoo , Cally Roper
关键词:
摘要: Sulfadoxine-pyrimethamine (SP) is used throughout Africa for intermittent preventive treatment (IPT) of malaria, but resistance threatens its efficacy. We found marked regional differences in the genotypes responsible SP when mapping recent surveys dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations. In West Africa, a 'partially resistant' combination dhfr N51I, N59R, S108N with dhps A437G predominates, whereas East 'fully A437G+K540E found. There are three African foci where populations have additionally acquired 581G and/or 164L to become 'super resistant'. SP-IPT infants pregnant women reported failed super resistant areas prompting review use affected areas.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(61)
Joris L. Likwela, Umberto D’Alessandro, Bernard L. Lokwa, Sylvain Meuris, Michele W. Dramaix, Sulfadoxine–pyrimethamine resistance and intermittent preventive treatment during pregnancy: a retrospective analysis of birth weight data in the Democratic Republic of Congo (DRC) Tropical Medicine & International Health. ,vol. 17, pp. 322- 329 ,(2011) , 10.1111/J.1365-3156.2011.02935.X
Mathieu Ndounga, Rachida Tahar, Leonardo K. Basco, Prisca N. Casimiro, David A. Malonga, Francine Ntoumi, Therapeutic efficacy of sulfadoxine-pyrimethamine and the prevalence of molecular markers of resistance in under 5-year olds in Brazzaville, Congo. Tropical Medicine & International Health. ,vol. 12, pp. 1164- 1171 ,(2007) , 10.1111/J.1365-3156.2007.01904.X
Linda Mobula, Philip J. Rosenthal, Bruce Lilley, Antoinette K. Tshefu, Resistance-mediating Polymorphisms in Plasmodium falciparum Infections in Kinshasa, Democratic Republic of the Congo The American Journal of Tropical Medicine and Hygiene. ,vol. 80, pp. 555- 558 ,(2009) , 10.4269/AJTMH.2009.80.555
DIDIER MENARD, FERDINAND YAPOU, DJIBRINE DJALLE, ANTOINE TALARMIN, ALEXANDRE MANIRAKIZA, FREQUENCY DISTRIBUTION OF ANTIMALARIAL DRUG-RESISTANT ALLELES AMONG ISOLATES OF PLASMODIUM FALCIPARUM IN BANGUI, CENTRAL AFRICAN REPUBLIC American Journal of Tropical Medicine and Hygiene. ,vol. 74, pp. 205- 210 ,(2006) , 10.4269/AJTMH.2006.74.205
Richard J. Pearce, Hirva Pota, Marie-Solange B. Evehe, El-Hadj Bâ, Ghyslain Mombo-Ngoma, Allen L. Malisa, Rosalynn Ord, Walter Inojosa, Alexandre Matondo, Diadier A. Diallo, Wilfred Mbacham, Ingrid V. van den Broek, Todd D. Swarthout, Asefaw Getachew, Seyoum Dejene, Martin P. Grobusch, Fanta Njie, Samuel Dunyo, Margaret Kweku, Seth Owusu-Agyei, Daniel Chandramohan, Maryline Bonnet, Jean-Paul Guthmann, Sian Clarke, Karen I. Barnes, Elizabeth Streat, Stark T. Katokele, Petrina Uusiku, Chris O. Agboghoroma, Olufunmilayo Y. Elegba, Badara Cissé, Ishraga E. A-Elbasit, Hayder A. Giha, S. Patrick Kachur, Caroline Lynch, John B. Rwakimari, Pascalina Chanda, Moonga Hawela, Brian Sharp, Inbarani Naidoo, Cally Roper, Multiple Origins and Regional Dispersal of Resistant dhps in African Plasmodium falciparum Malaria PLOS Medicine. ,vol. 6, ,(2009) , 10.1371/JOURNAL.PMED.1000055
C.T. Happi, G.O. Gbotosho, O.A. Folarin, D.O. Akinboye, B.O. Yusuf, O.O. Ebong, A. Sowunmi, D.E. Kyle, W. Milhous, D.F. Wirth, A.M.J. Oduola, Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria. Acta Tropica. ,vol. 95, pp. 183- 193 ,(2005) , 10.1016/J.ACTATROPICA.2005.06.015
Oumou Maïga, Abdoulaye A. Djimdé, Véronique Hubert, Emmanuelle Renard, Agnès Aubouy, Fred Kironde, Basile Nsimba, Kwadwo Koram, Ogobara K. Doumbo, Jacques Le Bras, Jérôme Clain, A Shared Asian Origin of the Triple-Mutant dhfr Allele in Plasmodium falciparum from Sites across Africa The Journal of Infectious Diseases. ,vol. 196, pp. 165- 172 ,(2007) , 10.1086/518512
Ishraga E A-Elbasit, Michael Alifrangis, Insaf F Khalil, Ib C Bygbjerg, Emad M Masuadi, Mustafa I Elbashir, Hayder A Giha, The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics. Malaria Journal. ,vol. 6, pp. 108- 108 ,(2007) , 10.1186/1475-2875-6-108
Cally Roper, Richard Pearce, Shalini Nair, Brian Sharp, François Nosten, Tim Anderson, Intercontinental Spread of Pyrimethamine-Resistant Malaria Science. ,vol. 305, pp. 1124- 1124 ,(2004) , 10.1126/SCIENCE.1098876
S. A. Omar, I. S. Adagu, D. W. Gump, N. P. Ndaru, D. C. Warhurst, Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area Annals of Tropical Medicine and Parasitology. ,vol. 95, pp. 661- 669 ,(2001) , 10.1080/00034980120103234