Attenuation of antigenic immunogenicity by kynurenine, a novel suppressive adjuvant.

摘要: A novel therapeutic strategy is required for autoimmune diseases characterized by the production of autoantibody, because current clinical strategies have limitations. Vaccination against a feasible vaccines induce immune response memory and antigen specificity. However, no suitable adjuvant available to direct toward tolerance or suppression. In study, we evaluated whether kynurenine (Kyn) could serve as suppressive decrease humoral responses hepatitis virus (HAV) in ICR mouse model vivo lipopolysaccharide (LPS) B cells vitro. The underlying mechanisms Kyn-mediated suppression LPS-induced IgM were explored. results showed that Kyn significantly decreased HAV immunogenicity when co-administered with HAV, (100 μM/1000 μM) impaired generation compared induced LPS alone. We also demonstrated microRNA30b (miR30b) played critical role process LPS, Bach2, transcriptional repressor cell terminal differentiation, was target miR30b. These findings suggest can effective vaccines.