Experimental evidences for miR-30b as a negative regulator of FOXO3 upregulated by kynurenine.
作者： Zhi-Qing Duan , Yan Li , Lu Li
DOI: 10.1007/S12026-017-8949-4
关键词: In vitro 、 Messenger RNA 、 FOXO3 、 Cancer cell 、 Cancer research 、 Kynurenine 、 Downregulation and upregulation 、 Biology 、 Metastasis 、 In vivo
摘要: Molecular constituents regulated by the microenvironment components profoundly influence propensity of cancer metastasis, a key event estimating therapeutic actions anticancer drugs. On one hand, kynurenine (Kyn), components, plays roles in metastasis cells vivo; on other forkhead box O3 (FOXO3) can serve as target various However, effect Kyn FOXO3 is still not clear. The current study demonstrated that selected dose significantly upregulated protein rather than messenger RNA (mRNA) lung 95D cells. only 50 μM markedly reduced miR-30b expression at same time. Furthermore, direct interaction between mRNA and was also confirmed dual-luciferase assay system. More importantly, miR-30b-induced suppression attenuated treatment, which Kyn-mediated increase depended least partly miR-30b. In addition, upregulation migration, method measuring decreased vitro, altered some degree via regulating FOXO3. These results suggest important Kyn-induced expression.
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