A randomized trial of prenatal ultrasonographic screening: Impact on the detection, management, and outcome of anomalous fetuses

摘要: Objective: The objective of this randomized clinical trial was to test the hypothesis that ultrasonographic screening would significantly alter perinatal outcome as a result antenatal detection fetal congenital malformations. Study Design: Pregnant women without specific indication for ultrasonography were randomly assigned have either two sonograms (15 22 weeks and 31 35 weeks) or conventional obstetric care with used only determined by judgment patient's physician. frequency birth defect in screened control populations compared, impact discovery on pregnancy outcome. Results: Major malformations occurred 2.3% 15,281 fetuses infants study. Antenatal detected 35% anomalous group versus 11 % population (relative rate 3.1; 95% confidence interval 2.0 5.1). Ultrasonography did not, however, influence management pregnancies complicated Specifically, 9 abortions performed anomalies among 7685 whereas 4 terminated 7596 subjects. also had no significant survival rates potentially treatable, life-threatening despite opportunity take precautionary measures such delivery tertiary center. Conclusions: low-risk pregnant abortion anomalies. Survival unaffected screening.