Advances in proteomic study of cardiac amyloidosis: progress and potential

摘要: ABSTRACTIntroduction: More than ten distinct forms of amyloidoses that can involve the heart have been described, classified according to which protein originates deposits. Cardiac amyloid infiltration translates into progressive and often life-threatening cardiomyopathy, but disease severity, prognosis treatment drastically differ amyloidosis type. The notion misfolding aggregation play a more general role in human cardiomyopathies has further raised attention towards definition proteotoxicity mechanisms.Areas covered: Mass spectrometry-based proteomics plays an important as diagnostic tool for understanding molecular bases cardiomyopathies. landscape applications study cardiac amyloid-related cardiotoxicity is summarized, with critical synthesis major achievements.Expert commentary: Current strengths limitations clinical setting translatio...