Estrogen metabolism and impaired spermatogenesis in germ cell tumors of the testis.

摘要: We evaluated spermatogenesis in 36 patients with germ cell tumors [11 seminoma (S) and 25 nonseminoma (NS)] terms of sperm concentration histological score (Johnsen's mean score) the ipsilateral contralateral testes. also measured steroid spermatic vein tumor-bearing side performed biochemical immunohistochemical studies aromatase activity tumor to investigate mechanism exocrine endocrine testicular dysfunction, particular emphasis on role estrogen metabolism. The was significantly lower S (42.9 +/- 40.7 x 10(8)/mL) NS (17.6 20.8 10(6)/mL) compared normal adult men (114.4 41.2 10(6) mL; P < 0.01). than S. highest testis, followed by testis far from near in...