Differential activity of bone marrow hematopoietic stem cell subpopulations for EPC development and ischemic neovascularization.
作者： Sang-Mo Kwon , Yun-Kyung Lee , Ayumi Yokoyama , Seok-Yun Jung , Haruchika Masuda
DOI: 10.1016/J.YJMCC.2011.04.007
关键词:
摘要: Although endothelial progenitor cells (EPCs) differentiate from minor populations of stem in bone marrow (BM), the differential role hematopoietic cell (HSC) subpopulations EPC development is largely unclear. Morphological characterization colonies has revealed that c-kit+/Sca-1+/lineage (Lin)-(KSL) mainly develop small EPC-colony forming units (CFUs) not large EPC-CFUs. In contrast, c-kit+/Sca-1-/Lin- (KL) EPC-CFUs Neither c-kit-/Sca-1+/Lin- (SL) nor c-kit-/Sca-1-/Lin- (L) to an appreciable extent. Hindlimb ischemia enhances formation all HSC subpopulations, suggesting important for functional development. Real time RT-PCR analysis shows KSL, KL and SL but L express various factors at high levels, maintaining a BM-EPC pool. hindlimb ischemia, transplanted efficiently into lineage situ augment capillary density. The percentage Ki-67+ cycling among ischemic tissue was also greater than cells. Moreover, frequency VEGF- or SDF-1-expressing higher Thus, are different their angiogenic competence under conditions. conclusion, although KSL clearly most potent contributors development, may contribute neovascularization via both autocrine paracrine mechanisms response signals.
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