Strategies for Improving Sensitivity for Targeted Quantitation by LC–MS

Jingduan Chi, Fumin Li, Rand Jenkins, Ultrasensitive sub-pg/ml determination of tiotropium bromide in human plasma by 2D-UHPLC-MS/MS: challenges and solutions. Bioanalysis. ,vol. 8, pp. 385- 395 ,(2016) , 10.4155/BIO.15.256

Yunlin Fu, Yuan-Qing Xia, Jimmy Flarakos, Francis L.S. Tse, Jeffrey D. Miller, Elliott B. Jones, Wenkui Li, Differential Mobility Spectrometry Coupled with Multiple Ion Monitoring in Regulated LC-MS/MS Bioanalysis of a Therapeutic Cyclic Peptide in Human Plasma Analytical Chemistry. ,vol. 88, pp. 3655- 3661 ,(2016) , 10.1021/ACS.ANALCHEM.5B04408

Gary A Schultz, Kathlyn McCardle, Hendrik Neubert, Large-scale implementation of sequential protein and peptide immunoaffinity enrichment LC/nanoLC–MS/MS for human β-nerve growth factor Bioanalysis. ,vol. 8, pp. 753- 764 ,(2016) , 10.4155/BIO-2015-0022

Yao-Yun Fan, Hendrik Neubert, Quantitative Analysis of Human Neonatal Fc Receptor (FcRn) Tissue Expression in Transgenic Mice by Online Peptide Immuno-Affinity LC-HRMS Analytical Chemistry. ,vol. 88, pp. 4239- 4247 ,(2016) , 10.1021/ACS.ANALCHEM.5B03900

Qian Ruan, Qin C. Ji, Mark E. Arnold, W. Griffith Humphreys, Mingshe Zhu, Strategy and Its Implications of Protein Bioanalysis Utilizing High-Resolution Mass Spectrometric Detection of Intact Protein Analytical Chemistry. ,vol. 83, pp. 8937- 8944 ,(2011) , 10.1021/AC201540T

Joe Palandra, Alyce Finelli, Ming Zhu, Jaime Masferrer, Hendrik Neubert, Highly specific and sensitive measurements of human and monkey interleukin 21 using sequential protein and tryptic peptide immunoaffinity LC-MS/MS. Analytical Chemistry. ,vol. 85, pp. 5522- 5529 ,(2013) , 10.1021/AC4006765

Guowen Liu, Yue Zhao, Aida Angeles, Lora L. Hamuro, Mark E. Arnold, Jim X. Shen, A novel and cost effective method of removing excess albumin from plasma/serum samples and its impacts on LC-MS/MS bioanalysis of therapeutic proteins. Analytical Chemistry. ,vol. 86, pp. 8336- 8343 ,(2014) , 10.1021/AC501837T

Eugene Ciccimaro, Asoka Ranasinghe, Celia D’Arienzo, Carrie Xu, Joelle Onorato, Dieter M. Drexler, Jonathan L. Josephs, Michael Poss, Timothy Olah, Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides. Analytical Chemistry. ,vol. 86, pp. 11523- 11527 ,(2014) , 10.1021/AC502678Y

Daniel Wilffert, Angela Asselman, Riccardo Donzelli, Jos Hermans, Natalia Govorukhina, Wim J Quax, Nico C van de Merbel, Rainer Bischoff, None, Highly sensitive antibody-free μLC-MS/MS quantification of rhTRAIL in serum. Bioanalysis. ,vol. 8, pp. 881- 890 ,(2016) , 10.4155/BIO.16.30

Xiaoguang (Sunny) Li, Shu Li, Gottfried Kellermann, An integrated liquid chromatography-tandem mass spectrometry approach for the ultra-sensitive determination of catecholamines in human peripheral blood mononuclear cells to assess neural-immune communication. Journal of Chromatography A. ,vol. 1449, pp. 54- 61 ,(2016) , 10.1016/J.CHROMA.2016.04.039