Differential Mobility Spectrometry Coupled with Multiple Ion Monitoring in Regulated LC-MS/MS Bioanalysis of a Therapeutic Cyclic Peptide in Human Plasma
作者： Yunlin Fu , Yuan-Qing Xia , Jimmy Flarakos , Francis L.S. Tse , Jeffrey D. Miller
DOI: 10.1021/ACS.ANALCHEM.5B04408
关键词:
摘要: A differential mobility spectrometry (DMS) in combination with a multiple ion monitoring (MIM) method was developed and validated for quantitative LC-MS/MS bioanalysis of pasireotide (SOM230) human plasma. Pasireotide, therapeutic cyclic peptide, exhibits poor collision-induced dissociation (CID) efficiency reaction (MRM) detection. Therefore, an effort to increase the overall sensitivity assay, DMS-MIM approach explored. By selecting most abundant doubly charged precursor both Q1 Q3 mass analyzer MIM combining DMS capability significantly reduce high matrix/chemical background noise, this new LC-DMS-MIM overcomes challenge typical MRM due CID fragmentation analyte. Human plasma spiked concentrations range 0.01–50 ng/mL. Weak cation-exchange solid-phase extraction employed sample preparation. The extracts were analyzed ...
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