Progression to type I diabetes in autoimmune endocrine patients with islet cell antibodies.

摘要: In an 11-yr screening program carried out on serum samples sent to autoimmune serology laboratory, 158 patients with clinical or subclinical endocrine manifestations and islet cell antibodies (ICAs) in the absence of overt diabetes were identified followed for development insulin-dependent (type I) diabetes. Twenty-two (13.9%) developed type I a follow-up up 12 yr (mean ± SE 4.8 3.2 yr). The probability being free was 69.8% at 10 after first detection ICAs. Progression disease influenced by 1 ) amount ICAs represented high titers (63% those ≥20 Juvenile Diabetes Foundation units yr), ICA persistency (59% diabetes; P 2 coexistence insulin autoantibodies (IAAs) (25% − ); 3 positive family history (1st-degree relative) (32%