Distinct cytoplasmic islet cell antibodies with different risks for type 1 (insulin-dependent) diabetes mellitus.
作者： S. Genovese , E. Bonifacio , J. M. McNally , B. M. Dean , R. Wagner
DOI: 10.1007/BF00401207
关键词:
摘要: The cytoplasmic islet cell antibody patterns of sera from positive non-diabetic and diabetic endocrine autoimmune patients, newly-diagnosed Type 1 (insulin-dependent) patients were characterised using four layer immunofluorescence with monoclonal antiproinsulin or anti-glucagon antibodies. Two distinct types identified. One gave a diffuse staining in both Beta Alpha cells (‘whole’ pattern), was not affected by pre-incubation rat brain homogenate. other had granular appearance restricted predominantly to (‘selective’ pattern) completely inhibited Some appeared have ‘mixed’ pattern, which glucagon-positive weaker than proinsulin-positive cells. ‘selective’ pattern found 19 (79%) 24 two (22%) who developed diabetes (p<0.0001 vs patients), none patients. ‘whole’ only had, subsequently progressed to, diabetes. This study has identified novel specificity demonstrates that antibodies stain are associated progression
springer.com
elsevier.com
sci-hub.se 参考文章(10)
D Doniach, G F Bottazzo, Islet-cell antibodies (ICA) in diabetes mellitus (evidence of an autoantigen common to all cells in the islet of Langerhans). La Ricerca in Clinica E in Laboratorio. ,vol. 8, pp. 29- 38 ,(1978)
C.C. Pilcher, R.B. Elliott, A sensitive and reproducible method for the assay of human islet cell antibodies. Journal of Immunological Methods. ,vol. 129, pp. 111- 117 ,(1990) , 10.1016/0022-1759(90)90427-W
E. Bonifacio, M. Shattock, B.M. Dean, G.F. Bottazzo, P.M. Bingley, E.A.M. Gale, D. Dunger, Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes The Lancet. ,vol. 335, pp. 147- 149 ,(1990) , 10.1016/0140-6736(90)90013-U
GianFranco Bottazzo, Richard Lendrum, SEPARATE AUTOANTIBODIES TO HUMAN PANCREATIC GLUCAGON AND SOMATOSTATIN CELLS The Lancet. ,vol. 308, pp. 873- 876 ,(1976) , 10.1016/S0140-6736(76)90538-9
M. Landin-Olsson, A. Karlsson, G. Dahlquist, L. Blom, �. Lernmark, G. Sundkvist, Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children. Diabetologia. ,vol. 32, pp. 387- 395 ,(1989) , 10.1007/BF00277264
Steinunn Baekkeskov, Henk-Jan Aanstoot, Stephan Christgai, Annette Reetz, Michele Solimena, Marilia Cascalho, Franco Folli, Hanne Richter-Olesen, Pietro-De Camilli, Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase Nature. ,vol. 347, pp. 151- 156 ,(1990) , 10.1038/347151A0
R. Gianani, A. Pugliese, S. Bonner-Weir, A. J. Shiffrin, J. S. Soeldner, H. Erlich, Z. Awdeh, C. A. Alper, R. A. Jackson, G. S. Eisenbarth, Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes. Diabetes. ,vol. 41, pp. 347- 353 ,(1992) , 10.2337/DIAB.41.3.347
E. Bosi, F. Becker, E. Bonifacio, R. Wagner, P. Collins, E. A. M. Gale, G. F. Bottazzo, Progression to type I diabetes in autoimmune endocrine patients with islet cell antibodies. Diabetes. ,vol. 40, pp. 977- 984 ,(1991) , 10.2337/DIAB.40.8.977
Michele Solimena, Franco Folli, Roxanne Aparisi, Guido Pozza, Pietro De Camilli, Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome New England Journal of Medicine. ,vol. 322, pp. 1555- 1560 ,(1990) , 10.1056/NEJM199005313222202
Steinunn Baekkeskov, Henk-Jan Aanstoot, Stephan Christgau, Annette Reetz, Michele Solimena, Marilia Cascalho, Franco Folli, Hanne Richter-Oleson, Pietro De Camilli, Erratum: Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase (Nature (1990) 347 (151-156)) Nature. ,vol. 347, ,(1990) , 10.1038/347782A0