Measurement of vancomycin hydrochloride concentration in the exudate from wounds receiving negative pressure wound therapy: a pilot study.

摘要: It has been reported that negative pressure wound therapy (NPWT) is effective in the treatment of contaminated wounds. We hypothesised systemically administered antibiotics migrate to site effectively by NPWT, which provides antibacterial effect. measured and compared concentrations vancomycin exudate blood serum. Eight patients with skin ulcers or defect wounds who were treated NPWT an intravenous drip enrolled this study. The surfaces muscle, muscle fascia adipose tissue. intravenously (1-3 g/day). was obtained using 500 ml V.A.C. ATS canisters without gel. Three days later, measured. mean concentration from 67% serum concentration. found exudates are higher than previously soft tissue NPWT. proactive use might be considered cases suspected contamination when a systemic antibiotic administered.