The tumor microenvironment and strategies to improve drug distribution.

摘要: The microenvironment within tumors is composed of a heterogeneous mixture cells with varying levels nutrients and oxygen. Differences in oxygen content result survival or compensatory mechanisms that may favor more malignant lethal phenotype. Cells are rapidly proliferating richly nourished preferentially located close to blood vessels. Chemotherapy can target kill adjacent the vasculature, while reside farther away often not exposed adequate amounts drug survive repopulate following treatment. characteristics tumor be manipulated order design effective therapies. In this review, we describe important features discuss strategies whereby distribution activity improved.