Quantitative Risk Assessment Relating to Adventitious Presence of Allergens in Food: A Probabilistic Model Applied to Peanut in Chocolate

摘要: Peanut allergy is a public health concern, owing to the high prevalence in France and severity of reactions. Despite peanut-containing product avoidance diets, risk may exist due adventitious presence peanut allergens wide range food products. not mentioned their ingredients list, but precautionary labeling often present. A method quantifying allergic reactions following consumption such products developed, taking example chocolate tablets. The occurrence proteins dose-response relationship are estimated with Bayesian approach using available published data. pattern described by French individual survey INCA2. Risk simulations performed second-order Monte Carlo simulations, which separately propagates variability uncertainty model input variables. occur approximately 36% chocolates, leading mean exposure level 0.2 mg per eating occasion. reaction averages 0.57% occasion for peanut-allergic adults. 95% values stand between 0 3.61%, illustrates variability. uncertainty, represented credible intervals, concentrated around these estimates. Children have similar results. conclusion that induce part population. developed can be generalized assess every foodstuff potentially contaminated allergens.