The many facets of adenine: coordination, crystal patterns, and catalysis

摘要: Canonical purine−pyrimidine base pairs, the key to complementary hydrogen bonding in nucleic acids, are fundamental molecular recognition motifs crucial for formation and stability of double-helical DNA. Consequently, focused study modeling nucleobase hydrogen-bonding schemes have spawned a vast array chemical biophysical investigations. The Watson−Crick, reverse Hoogsteen, Hoogsteen stabilize various acid structures. As result, numerous modified bases been designed maximize such interactions, addressing specific problems related pairing giving rise supramolecular ensembles solution or solid state. It is also important realize that suitably predisposed imino nitrogens other functional groups present heterocyclic nucleobases versatile framework construction coordination architectures, which may be harnessed mimic polyads higher order nuclei...