Polarizing currents increase noradrenaline-elicited accumulation of cyclic AMP in rat cerebral cortex
作者： Akiyoshi Moriwaki
DOI: 10.1016/0006-8993(91)90061-Y
关键词:
摘要: Cyclic AMP accumulation elicited by noradrenaline was determined in cerebral cortical slices of rats 24 h after an application weak anodal direct current (anodal polarization) to the surface sensorimotor cortex. Noradrenaline-elicited cyclic altered regionally polarization relation duration and intensity polarizing current. The highest left anterior region including polarized point under conditions 0.3 microA for 1.5 3.0 30 min. Under these two conditions, higher than that non-polarized control same region. Furthermore, beta-adrenergic antagonist propranolol almost completely reduced level. These results suggest enhances activity noradrenaline-sensitive generating systems through mechanisms as a function both cortex one event has long-lasting aftereffect on
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