1-[2-(4-Isobutyl-phen-yl)propano-yl]thiosemicarbazide.

作者: Hoong-Kun Fun , Reza Kia , Samuel Robinson Jebas , K. V. Sujith , B. Kalluraya

DOI: 10.1107/S1600536809006527

关键词:

摘要: In the title compound, C14H21N3OS, inter­molecular N—H⋯O inter­actions generate ten-membered rings with R22(10) ring motifs, whereas N—H⋯S eight, 14- and 16-membered R22(8), R44(14) R44(16) respectively. There are weak intra­molecular N—H⋯π which might influence conformation of mol­ecule. The compound has a stereogenic center but space group is centrosymmetic so mol­ecule exists as racemate.

参考文章(10)
Walter F Kean, W Watson Buchanan, The use of NSAIDs in rheumatic disorders 2005: a global perspective. Inflammopharmacology. ,vol. 13, pp. 343- 370 ,(2005) , 10.1163/156856005774415565
Joel Bernstein, Raymond E. Davis, Liat Shimoni, Ning-Leh Chang, Patterns in Hydrogen Bonding: Functionality and Graph Set Analysis in Crystals Angewandte Chemie. ,vol. 34, pp. 1555- 1573 ,(1995) , 10.1002/ANIE.199515551
J. Cosier, A. M. Glazer, A nitrogen‐gas‐stream cryostat for general X‐ray diffraction studies Journal of Applied Crystallography. ,vol. 19, pp. 105- 107 ,(1986) , 10.1107/S0021889886089835
Shinichi Kawai, Fumiaki Kojima, Natsuko Kusunoki, Recent Advances in Nonsteroidal Anti-Inflammatory Drugs Allergology International. ,vol. 54, pp. 209- 215 ,(2005) , 10.2332/ALLERGOLINT.54.209
M.S.Y. Khan, Mymoona Akhter, Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen European Journal of Medicinal Chemistry. ,vol. 40, pp. 371- 376 ,(2005) , 10.1016/J.EJMECH.2004.11.009
Niels Mørk Nielsenw, Hans Bundgaard, Glycolamide Esters as Biolabile Prodrugs of Carboxylic Acid Agents: Synthesis, Stability, Bioconversion, and Physicochemical Properties Journal of Pharmaceutical Sciences. ,vol. 77, pp. 285- 298 ,(1988) , 10.1002/JPS.2600770402
Xiangguo Zhao, Xinyi Tao, Dongzhi Wei, Qingxun Song, Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates European Journal of Medicinal Chemistry. ,vol. 41, pp. 1352- 1358 ,(2006) , 10.1016/J.EJMECH.2006.05.014
George M. Sheldrick, A short history of SHELX Acta Crystallographica Section A. ,vol. 64, pp. 112- 122 ,(2008) , 10.1107/S0108767307043930
Anthony L. Spek, Structure validation in chemical crystallography Acta Crystallographica Section D-biological Crystallography. ,vol. 65, pp. 148- 155 ,(2009) , 10.1107/S090744490804362X
Joel Epstein, Gary D Klasser, Nonsteroidal anti-inflammatory drugs: confusion, controversy and dental implications. Journal of The Canadian Dental Association. ,vol. 71, pp. 575- 580 ,(2005)