Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates
作者： Xiangguo Zhao , Xinyi Tao , Dongzhi Wei , Qingxun Song
DOI: 10.1016/J.EJMECH.2006.05.014
关键词:
摘要: Abstract Novel ester prodrugs (II, III and IV) of ibuprofen (I) were synthesized using α-methyl, ethyl propyl glucopyranoside as promoieties tested for their anti-inflammatory, analgesic ulcerogenic activities. Study chemical hydrolysis in aqueous buffer (pH 3.0–10.0) showed that these compounds acted true ibuprofen, giving the alkyl glucopyranoside. Additionally, all derivatives studied did cleave rapidly inside biological system on oral administration elicit a pharmacological profile quite similar to but, unlike this drug, they displayed reduced gastric ulceration. In conclusion, esters have promising properties delivery ibuprofen.
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