High incidence of and risk factors for metachronous bilateral upper tract urothelial carcinoma in Taiwan

摘要: Aim:  Urothelial carcinoma (UC) can occur multifocally in the whole urothelium. A higher rate of bilateral metachronous upper tract (UT) UC was noted Taiwan. The incidence and risk factors were largely unknown hence explored study. Methods:  From January 1977 through June 2003, 462 patients with unilateral UT-UC studied retrospectively. cumulative contralateral recurrence analysed Kaplan–Meier analysis. Potential for including age, smoking, bladder cancer, renal function, diagnostic year etc. evaluated log–rank test. Independent identified by using Cox regression analysis. Results:  median follow-up time 34 months (6–337). Among patients, 52 (11.3%) developed UC. 2, 5, 10-year disease-free survivals 93.5%, 84.0%, 75.7%, respectively. to 31.0 months. With univariate analysis, only poor function (serum creatinine < or ≥2.0 mg/dL, P < 0.001) late (before after 1990, recurrence. In multivariate (hazard ratio: 2.98; 95% confidence interval: 1.67–5.33; 4.27; 1.71–10.65; P = 0.002) remained independent factors. Conclusions:  is high Patients who had either chronic insufficiency a disease diagnosed 1990