Methods and compositions for the treatment of immune disorders

作者: Jenny P.-Y. Ting , Haitao Wen

DOI:

关键词:

摘要: The present invention provides a method of treating an immune-related disorder in subject, comprising administering to the subject effective amount inhibitor plexin-A4 activity, which results reducing activity and thereby disorder. Inhibitors include, for example, antibodies fusion proteins. further semaphorin-3A (Sema3A) Sema3A

参考文章(33)
Pieter R. Cullis, Lawrence D. Mayer, Nancy L. Boman, Marcel B. Bally, Liposomal compositions for enhanced retention of bioactive agents ,(1993)
Marie C. Defrances, Abdolreza Zarnegar, Chun-Bin Zou, Cell death modulation via antagonists of Fasl and Fas activation ,(2005)
Bryan Zerhusen, Peter Mezes, Catherine Burgess, Sudhirdas Prayaga, Richard Shimkets, Luca Rastelli, Novel Proteins and nucleic acids encoding the same ,(2002)
Athena W Wong, W June Brickey, Debra J Taxman, Hendrick W van Deventer, William Reed, Jian Xin Gao, Pan Zheng, Yang Liu, Ping Li, Janice S Blum, Karen P McKinnon, Jenny P-Y Ting, CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Nature Immunology. ,vol. 4, pp. 891- 898 ,(2003) , 10.1038/NI960
Kelly E. Roney, Brian P. O'Connor, Haitao Wen, Eda K. Holl, Elizabeth H. Guthrie, Beckley K. Davis, Stephen W. Jones, Sushmita Jha, Lisa Sharek, Rafael Garcia-Mata, James E. Bear, Jenny P.-Y. Ting, Plexin-B2 Negatively Regulates Macrophage Motility, Rac, and Cdc42 Activation PLoS ONE. ,vol. 6, pp. e24795- ,(2011) , 10.1371/JOURNAL.PONE.0024795
Avraham Yaron, Pei-Hsin Huang, Hwai-Jong Cheng, Marc Tessier-Lavigne, Differential Requirement for Plexin-A3 and -A4 in Mediating Responses of Sensory and Sympathetic Neurons to Distinct Class 3 Semaphorins Neuron. ,vol. 45, pp. 513- 523 ,(2005) , 10.1016/J.NEURON.2005.01.013
Wei Shi, Atsushi Kumanogoh, Chie Watanabe, Junji Uchida, Xiaosong Wang, Teruhito Yasui, Kazunori Yukawa, Masahito Ikawa, Masaru Okabe, Jane R Parnes, Kanji Yoshida, Hitoshi Kikutani, The Class IV Semaphorin CD100 Plays Nonredundant Roles in the Immune System Immunity. ,vol. 13, pp. 633- 642 ,(2000) , 10.1016/S1074-7613(00)00063-7
Atsumasa Okada, Mitsutoshi Tominaga, Makoto Horiuchi, Yasuhiro Tomooka, Plexin-A4 is expressed in oligodendrocyte precursor cells and acts as a mediator of semaphorin signals Biochemical and Biophysical Research Communications. ,vol. 352, pp. 158- 163 ,(2007) , 10.1016/J.BBRC.2006.10.176