作者: P. J. Radlett
DOI: 10.1007/BFB0000677
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摘要: The isolation of Baby Hamster Kidney (BHK) 21 cells and their adaptation, characterisation development for the commercial manufacture foot mouth disease vaccines over a twenty year period is reviewed, including preparation media, handling cell substrates control physical environment during manufacture. A description given successful operation BHK process which depends on series manufacturing stages, all make an essential contribution to final quality product are complementary ultimate assessment as defined by testing.