Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk.
作者： Monique Saintot , Christian Malaveille , Agn�s Hautefeuille , Mariette Gerber
DOI: 10.1002/IJC.11432
关键词:
摘要: Genetic polymorphisms of enzymes involved in the metabolism xenobiotics and estrogens might play a role breast carcinogenesis related to environmental exposures. In case-only study on 282 women with cancer, we studied interaction effects (ORi) between smoking habits gene Cytochrome P450 1B1 (Val432Leu CYP1B1), Phenol-sulfotransferase 1A1 (Arg213His SULT1A1) Catechol-O-methyltransferase (Val158Met COMT). The smokers carrying ValCYP1B1 allele associated high hydroxylation activity had higher risk cancer than never Leu/Leu genotype (ORi=2.32, 95%CI: 1.00–5.38). Also, HisSULT1A1 low sulfation 2-fold excess compared Arg/Arg SULT1A1 common (ORi= 2.55, 1.21–5.36). increased only premenopausal patients. Met COMT lower methylation ValCOMT did not modify among smokers. due joint effect could result from exposure activated tobacco-compounds for homo/heterozygous allele. tobacco carcinogens increase genotoxic compounds. Alternatively, Val CYP1B1 or His modified ability metabolize level catechol estrogen (i.e., 4-hydroxy-estradiol) Our showed that induce an individual susceptibility current © 2003 Wiley-Liss, Inc.
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