Cancer and molecular biomarkers of phase 2.
作者： Kim Dalhoff , Kaspar Buus Jensen , Henrik Enghusen Poulsen
DOI: 10.1016/S0076-6879(05)00035-2
关键词:
摘要: Abstract Associations between genotypes of phase 2 enzymes and cancer risk are extracted from epidemiological studies, namely case–control studies. Variant alleles in glutathione S ‐transferase (GST), UDP‐glucuronosyltransferase (UGT), sulfotransferase (SULT), N ‐acetyltransferase (NAT) have been used as molecular genetic biomarkers risk. GSTM(my)1 has associated with an increased colorectal cancer, lung bladder GSTP(pi)1 prostate cancer. UGT1A1*28 *37 both breast is SULT1A1*2. The presence results ovarian NAT2 A high frequency SULT1A1*1 identified patients cancer; the role more controversial. This chapter discusses balance carcinogen activation detoxification relation to enzymes.
elsevier.com
cpnc.dk 参考文章(32)
Lord Hl, Grant Dm, Morrison Ld, Josephy Pd, Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines. Cancer Research. ,vol. 52, pp. 3961- 3964 ,(1992)
Chantal Guillemette, David E. Housman, Beth Newman, Robert C. Millikan, Genetic Polymorphisms in Uridine Diphospho-Glucuronosyltransferase 1A1 and Association with Breast Cancer among African Americans Cancer Research. ,vol. 60, pp. 950- 956 ,(2000)
David W. Hein, Acetylator genotype and arylamine-induced carcinogenesis. Biochimica et Biophysica Acta. ,vol. 948, pp. 37- 66 ,(1988) , 10.1016/0304-419X(88)90004-2
M. BLUM, D.M. GRANT, W. McBRIDE, M. HEIM, U.A. MEYER, Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. DNA and Cell Biology. ,vol. 9, pp. 193- 203 ,(1990) , 10.1089/DNA.1990.9.193
AD Lewis, LM Forrester, JD Hayes, CJ Wareing, J Carmichael, AL Harris, M Mooghen, CR Wolf, Glutathione S-transferase isoenzymes in human tumours and tumour derived cell lines. British Journal of Cancer. ,vol. 60, pp. 327- 331 ,(1989) , 10.1038/BJC.1989.280
Martin Yuille, Alison Condie, Chantelle Hudson, Zsofia Kote-Jarai, Elaine Stone, Rosalind Eeles, Estella Matutes, Daniel Catovsky, Richard Houlston, Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. Blood. ,vol. 99, pp. 4216- 4218 ,(2002) , 10.1182/BLOOD.V99.11.4216
R. A. H. J. Gilissen, K. J Bamforth, J. F. C. Stavenuiter, M. W. H. Coughtrie, J. N. H. Meerman, Sulfation of aromatic hydroxamic acids and hydroxylamines by multiple forms of human liver sulfotransferases Carcinogenesis. ,vol. 15, pp. 39- 45 ,(1994) , 10.1093/CARCIN/15.1.39
Edward J. Carlini, Rebecca B. Raftogianis, Thomas C. Wood, Fan Jin, Wei Zheng, Timothy R. Rebbeck, Richard M. Weinshilboum, Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects. Pharmacogenetics. ,vol. 11, pp. 57- 68 ,(2001) , 10.1097/00008571-200102000-00007
Yunfei Wang, Margaret R. Spitz, Amy Meng-Hsuan Tsou, Kerang Zhang, Nimisha Makan, Xifeng Wu, Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis Lung Cancer. ,vol. 35, pp. 137- 142 ,(2002) , 10.1016/S0169-5002(01)00406-8
Christopher A. Haiman, Susan E. Hankinson, Immaculata De Vivo, Chantal Guillemette, Naoko Ishibe, David J. Hunter, Celia Byrne, Polymorphisms in Steroid Hormone Pathway Genes and Mammographic Density Breast Cancer Research and Treatment. ,vol. 77, pp. 27- 36 ,(2003) , 10.1023/A:1021112121782