Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility.
作者： Han-chun Chen , Wei-xin Hu , Qing-xia Liu , Wen-kai Li , Fang-zhi Chen
DOI: 10.1097/CEJ.0B013E3282B72093
关键词:
摘要: The genetic polymorphisms of biotransformation phase I enzymes, cytochrome P450 (CYP1A1 and CYP2D6), II glutathione S-transferase (GSTM1 GSTT1), were analyzed in 204 healthy persons 348 leukemia patients, who suffered from also acute lymphoblastic (ALL), nonlymphoblastic (ANLL) chronic myelogenous (CML), the Han ethnic group Changsha City Hunan Province China. Our results showed that frequencies CYP1A1, CYP2D6 GSTT1 among groups including leukemia, ANLL, control have no significant differences. variation GSTM1-null genotype alone correlated with development ANLL. combined genotypes GSTT1-null, or CYP1A1 heterozygous mutant, mutant GSTT1-null found individuals high risk All these findings suggest coordination relevant other metabolic enzymes might be susceptibility factors etiology
sci-hub.se 参考文章(59)
Maja Krajinovic, Damian Labuda, Chantal Richer, Sepideh Karimi, Daniel Sinnett, Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms Blood. ,vol. 93, pp. 1496- 1501 ,(1999) , 10.1182/BLOOD.V93.5.1496
D W Nebert, O W McBride, K Ikeya, D D Petersen, A E Bale, H H Smith, C E McKinney, Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP. American Journal of Human Genetics. ,vol. 48, pp. 720- 725 ,(1991)
Kim Dalhoff, Kaspar Buus Jensen, Henrik Enghusen Poulsen, Cancer and molecular biomarkers of phase 2. Methods in Enzymology. ,vol. 400, pp. 618- 627 ,(2005) , 10.1016/S0076-6879(05)00035-2
Ingolf Cascorbi, Jürgen Brockmöller, Ivar Roots, Reinhold Kerb, Combined Analysis of Inherited Polymorphisms in Arylamine N-Acetyltransferase 2, Glutathione S-Transferases M1 and T1, Microsomal Epoxide Hydrolase, and Cytochrome P450 Enzymes as Modulators of Bladder Cancer Risk Cancer Research. ,vol. 56, pp. 3915- 3925 ,(1996)
S Pemble, K R Schroeder, S R Spencer, D J Meyer, E Hallier, H M Bolt, B Ketterer, J B Taylor, Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochemical Journal. ,vol. 300, pp. 271- 276 ,(1994) , 10.1042/BJ3000271
M. Ingelman-Sundberg, F. Sjoqvist, L. Bertilsson, I. Johansson, Qun-Ying Yue, M. Oscarson, Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Molecular Pharmacology. ,vol. 46, pp. 452- 459 ,(1994)
Sarah C. Sim, Magnus Ingelman-Sundberg, The Human Cytochrome P450 Allele Nomenclature Committee Web Site: Submission Criteria, Procedures, and Objectives Cytochrome P450 Protocols. ,vol. 320, pp. 183- 192 ,(2006) , 10.1385/1-59259-998-2:183
Wei Cao, Lin Cai, Jian-Yu Rao, Allan Pantuck, Ming-Lan Lu, Guido Dalbagni, Victor Reuter, Howard Scher, Carlos Cordon-Cardo, Robert A. Figlin, Arie Belldegrun, Zuo-Feng Zhang, Tobacco smoking, GSTP1 polymorphism, and bladder carcinoma Cancer. ,vol. 104, pp. 2400- 2408 ,(2005) , 10.1002/CNCR.21446
Daniel Sinnett, Maja Krajinovic, Damian Labuda, Genetic susceptibility to childhood acute lymphoblastic leukemia. Leukemia & Lymphoma. ,vol. 38, pp. 447- 462 ,(2000) , 10.3109/10428190009059264
M T Landi, P A Bertazzi, P G Shields, G Clark, G W Lucier, S J Garte, G Cosma, N E Caporaso, Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics. ,vol. 4, pp. 242- 246 ,(1994) , 10.1097/00008571-199410000-00002