A Prospective Study of Aspirin Use and Primary Prevention of Cardiovascular Disease in Women

摘要: Objective. —The aim of the study was to examine prospectively association between regular aspirin use and risk a first myocardial infarction other cardiovascular events in women. Design. —Prospective cohort including 6 years follow-up. Setting.—Registered nurses residing 11 US states. Participants. —US registered (n = 87 678) aged 34 65 free diagnosed coronary heart disease, stroke, cancer at baseline. Follow-up 96.7% total potential person-years Main Outcome Measures. —Incidence infarction, death, all important vascular events. Results. —During 475 265 follow-up, we documented 240 nonfatal infarctions, 146 strokes, 130 deaths due disease (total, 516 events). Among women who reported taking one through six per week, age-adjusted relative (RR) 0.68 (95% confidence interval [CI], 0.52 0.89; P =.005), as compared with those took no aspirin. After simultaneous adjustment for factors RR 0.75 CI, 0.58 0.99; =.04). For 50 older, 0.61 0.45 0.84; =.002) multivariate 0.50 0.93; =.02). We observed alteration stroke (multivariate =.94). The death 0.89 (P =.56) 0.85 =.12). When examined separately, results were nearly identical subgroups three four though week. seven or more there apparent reductions risk. Conclusions. week appears be associated reduced among A randomized trial is necessary, however, provide conclusive data on role primary prevention (JAMA. 1991;266:521-527)