Human Papilloma Virus and Chlamydia trachomatis: Casual Acquaintances or Partners in Crime?

摘要: Interactions between microorganisms can alter subsequent disease outcomes. Human papilloma virus (HPV) and Chlamydia trachomatis (CT) establish human genital co-infections, CT infection is a co-factor for HPV-induced cervical cancer. This review focuses upon (i) data indicating that clinically significant interactions occur (ii) proposed mechanisms underlying these Epidemiological surveys indicate simultaneous HPV/CT co-infections are common; co-infection accelerates cytopathology; (iii) HPV facilitates infection. Single-infection studies suggest specific molecular by which alters clinical outcomes, including E6/E7 protein modification of host cell pathways enhances replication or immune evasion CT-mediated neutrophil dysfunctions promote HPV-mediated neoplasia. There multiple avenues future dissection interactions. Moreover, the known potential health consequences highlight need improving current vaccines developing an effective vaccine.