Chlamydia trachomatis Causes Centrosomal Defects Resulting in Chromosomal Segregation Abnormalities
作者： Scott S. Grieshaber , Nicole A. Grieshaber , Natalie Miller , Ted Hackstadt
DOI: 10.1111/J.1600-0854.2006.00439.X
关键词:
摘要: Chlamydiae traffic along microtubules to the microtubule organizing center (MTOC) establish an intracellular niche within host cell. Trafficking MTOC is dynein dependent although activating and cargo-linking function of dynactin complex supplanted by unknown chlamydial protein(s). We demonstrate that once localized MTOC, inclusion maintains a tight association with cellular centrosomes. This sustained through mitosis leads significant increase in supernumerary centrosomes, abnormal spindle poles, chromosomal segregation defects. Chlamydial infection thus can lead chromosome instability cells recover from infection.
sci-hub.se 参考文章(47)
Dale Howe, Lorraine F. Barrows, Nicole M. Lindstrom, Robert A. Heinzen, Nitric oxide inhibits Coxiella burnetii replication and parasitophorous vacuole maturation. Infection and Immunity. ,vol. 70, pp. 5140- 5147 ,(2002) , 10.1128/IAI.70.9.5140-5147.2002
Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infection and Immunity. ,vol. 31, pp. 1161- 1176 ,(1981) , 10.1128/IAI.31.3.1161-1176.1981
Johannes D. Clausen, Gunna Christiansen, Henrik U. Holst, Svend Birkelund, Chlamydia trachomatis utilizes the host cell microtubule network during early events of infection Molecular Microbiology. ,vol. 25, pp. 441- 449 ,(1997) , 10.1046/J.1365-2958.1997.4591832.X
Alistair J. Lax, Warren Thomas, How bacteria could cause cancer: one step at a time Trends in Microbiology. ,vol. 10, pp. 293- 299 ,(2002) , 10.1016/S0966-842X(02)02360-0
T Hackstadt, R Messer, W Cieplak, M G Peacock, Evidence for proteolytic cleavage of the 120-kilodalton outer membrane protein of rickettsiae: identification of an avirulent mutant deficient in processing. Infection and Immunity. ,vol. 60, pp. 159- 165 ,(1992) , 10.1128/IAI.60.1.159-165.1992
Matti Hakama, Matti Lehtinen, Paul Knekt, Arpo Aromaa, Pauli Leinikki, Ari Miettinen, Jorma Paavonen, Richard Peto, Lyly Teppo, None, Serum Antibodies and Subsequent Cervical Neoplasms: A Prospective Study with 12 Years of Follow-up American Journal of Epidemiology. ,vol. 137, pp. 166- 170 ,(1993) , 10.1093/OXFORDJOURNALS.AJE.A116656
S. F. B. Berkley, J. T. Rowley, P. Piot, A. C. Gerbase, D. H. L. Heymann, Global prevalence and incidence estimates of selected curable STDs. Sexually Transmitted Infections. ,vol. 74, ,(1998)
K. Boller, W. Schmid, Chemical mutagenesis in mammals. The Chinese hamster bone marrow as an in vivo test system. Hematological findings after treatment with trenimon Human Genetics. ,vol. 11, pp. 35- 54 ,(1970) , 10.1007/BF00296302
Karl Münger, Stefan Duensing, The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Research. ,vol. 62, pp. 7075- 7082 ,(2002)
Stephen J. Doxsey, German A. Pihan, Yening Zhou, Jan Wallace, Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Research. ,vol. 63, pp. 1398- 1404 ,(2003)