The essential role of MTDH in the progression of HCC: a study with immunohistochemistry, TCGA, meta-analysis and in vitro investigation.
作者： Yiwu Dang , Rongquan He , Lihua Yang , Zhigang Peng , Gang Chen
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摘要: Recent studies found that metadherin (MTDH) played an essential role in hepatocellular carcinoma (HCC). Nevertheless, the exact function of MTDH pathogenesis HCC was unclarified. In present study, we aimed to investigate clinical significance and its effect on cells. Immunohistochemistry (IHC) performed detect expression tissues. Data from The Cancer Genome Atlas (TCGA) ONCOMINE obtained examine significance. Meta-analysis conducted assess correlation between both prognosis (Overall Survival (OS) or Disease-free (DFS)) clinicopathological features via STATA 12.0. vitro experiments were cell growth, caspase-3/7 activity apoptosis staining remarkably stronger tissues than non-cancer IHC, TCGA data. Moreover, MTDH-positive significantly correlated with pathological grade, distant metastasis hepatitis B virus (HBV) infection by IHC. For meta-analysis, indicative poor OS without heterogeneity patients. Additionally, high-grade histological differentiation, non-vascular invasion HCC. revealed could inhibit growth activate four lines. conclusion, may serve as a novel targeting strategy for due oncogenic
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