Pseudobulbar affect: prevalence and quality of life impact in movement disorders.

摘要: Pseudobulbar affect (PBA) is an affective disinhibition syndrome characterized by sudden, involuntary outbursts of inappropriate crying or laughing. We have previously reported the prevalence PBA in movement disorders using interviewer-administered questionnaire that had not been validated. In current study, a validated self-administered screening instrument, Center for Neurologic Study-Lability Scale (CNS-LS), was used to study PBA, its association with mood symptoms, and quality life impact. Two hundred sixty-nine patients met inclusion criteria (consent, age > 18 years, formal diagnosis, completion CNS-LS). The CNS-LS assess at cutoff score 17 (utilized from multiple sclerosis studies). Beck Depression Inventory (BDI) scale Parkinson's disease (PDQ-39) were depressive symptoms life. Logistic regression analysis predict associations PBA. prevalent 7.1% (n = 19) disorder patients. No significant difference observed patient diagnosis: (12/168) (PD), 11.4% (4/35) essential tremor, 0% (0/13) dystonia, (0/16) psychogenic disorders, 10.7% (3/28) other disorders. Patients higher BDI depression scores (p < 0.0001) lower PDQ-39 emotional well-being subscores 0.0001). taking antidepressant medications significantly rates 0.0008). PD all tend more poorer