Increases of glial fibrillary acidic protein in the aging female mouse brain
作者： Steven G. Kohama , James R. Goss , Caleb E. Finch , Thomas H. McNeill
DOI: 10.1016/0197-4580(95)80008-F
关键词:
摘要: Age-related increases of the astrocyte marker, glial fibrillary acidic protein (GFAP), were further resolved by in situ hybridization and immunocytochemistry female C57BL/6J mice. The age groups represented major stages reproductive aging: young (5 months), middle-age (18 old (23 26 months). GFAP mRNA showed generalized Major white fiber tracts, such as corpus callosum, fimbria, stria terminalis, optic tract, increased immunostaining mRNA. Gray matter robust > or = twofold with age, especially thalamus hypothalamus, areas that expressed little young. These age-related many brain regions imply existence a widespread stimulus for activity astrocytes during aging.
elsevier.com
sci-hub.se 参考文章(45)
N Akagi, M Shimada, M Nakanishi, H Goto, H Watanabe, Y Hirose, M Watanabe, Microvessel and astroglial cell densities in the mouse hippocampus. Journal of Anatomy. ,vol. 180, pp. 89- 95 ,(1992)
M. K�lm�n, F. Haj�s, Distribution of glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes in the rat brain. I. Forebrain. Experimental Brain Research. ,vol. 78, pp. 147- 163 ,(1989) , 10.1007/BF00230694
Jane A. Langdale, In situ Hybridization Springer, New York, NY. pp. 165- 180 ,(1994) , 10.1007/978-1-4612-2694-9_18
TO Brock, JP O'Callaghan, Quantitative changes in the synaptic vesicle proteins synapsin I and p38 and the astrocyte-specific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system. The Journal of Neuroscience. ,vol. 7, pp. 931- 942 ,(1987) , 10.1523/JNEUROSCI.07-04-00931.1987
Nikki J. Holbrook, Thomas E. Johnson, Edward L. Schneider, John H. Morrison, John W. Rowe, Handbook of the Biology of Aging ,(1990)
Paul D. Coleman, Dorothy G. Flood, Neuron numbers and dendritic extent in normal aging and Alzheimer's disease Neurobiology of Aging. ,vol. 8, pp. 521- 545 ,(1987) , 10.1016/0197-4580(87)90127-8
Carmen de la Rosa, Josefina Cano, Fernando Reinoso-suárez, An electron microscopic study of astroglia and oligodendroglia in the lateral geniculate nucleus of aged rats Mechanisms of Ageing and Development. ,vol. 29, pp. 267- 281 ,(1985) , 10.1016/0047-6374(85)90067-3
James R. Goss, Caleb E. Finch, David G. Morgan, Age-related changes in glial fibrillary acidic protein mRNA in the mouse brain. Neurobiology of Aging. ,vol. 12, pp. 165- 170 ,(1991) , 10.1016/0197-4580(91)90056-P
Kimberly S. Topp, Brian T. Faddis, Vijaya K. Vijayan, Trauma-induced proliferation of astrocytes in the brains of young and aged rats. Glia. ,vol. 2, pp. 201- 211 ,(1989) , 10.1002/GLIA.440020309
Inta Adams, D.G. Jones, Synaptic remodelling and astrocytic hypertrophy in rat cerebral cortex from early to late adulthood Neurobiology of Aging. ,vol. 3, pp. 179- 186 ,(1982) , 10.1016/0197-4580(82)90038-0