Opioid Receptors in the Sympathetic Supply to Blood Vessels and the Heart

摘要: Presynaptic inhibition by morphine of action potential-evoked release noradrenaline was first shown in the nictitating membrane cat (Trendelenburg 1957). An analogous found, for instance, mouse vas deferens and rat brain regions (for review see Starke 1977; Henderson et al. 1979) but, remarkably, not several other tissues such as spleen (Cairnie 1961), rabbit heart (Montel 1973), ear artery (Knoll 1976), guinea pig atria (Ledda 1984). This sharp distinction between morphine-sensitive morphine-insentitive noradrenergic neurons has been modified detection opioid receptor subtypes selectivity classical opiates mu-type only. sympathetic transmission enkephalins (now known to be delta-selective) a morphine-insensitive tissue described Knoll (1976) rabbit. The axons innervating (Gaddis Dixon 1982), (Starke 1985), 1984; Fuder 1986) also apparently lack mu-receptors but do possess release-inhibiting delta- or kappa-receptors. Since these observations opened up new possibility cardiovascular effects exogenous drugs even control endogenous opioids, we carried out systematic search prejunctional receptors at postganglionic Agonists antagonists selective mu-, delta-, kappa-receptors (see Paterson 1983; James Goldstein Kosterlitz 1985) were used studies.