Determination of Diethanolamine and N-Nitrosodiethanolamine in Fatty Acid Diethanolamides

摘要: Diethanolamine (DEA) is a precursor of N-nitrosodiethanolamine (NDELA), an animal carcinogen. A gas chromatographic (GC) method was developed for determining DEA in fatty acid diethanolamides that are commonly used cosmetic products. Methanolic solutions the amides were analyzed by GC with flame ionization detection on either wide-bore methyl silicone (Rt x -1) or 95% dimethyl-5% diphenyl polysiloxane (SPB-5) capillary column. Recovery from dialkanolamides at fortification levels 0.50, 1.00, and 5.00% ranged 94 to 100%. In survey commercial diethanolamides, found ranging 1.1 14.0%, most good agreement manufacturer's specifications. Fatty also NDELA liquid chromatography interfaced thermal energy analyzer. 50, 100, 200 ppb averaged 95%. No any diethanolamide samples analyzed.