Monitoring of N-nitrosodiethanolamine in cosmetic products by ion-pair complex liquid chromatography and identification with negative ion electrospray ionization mass spectrometry.
作者： Alireza Ghassempour , Monireh Abbaci , Zahra Talebpour , Bernhard Spengler , Andreas Römpp
DOI: 10.1016/J.CHROMA.2007.12.045
关键词:
摘要: A high-performance liquid chromatographic (HPLC) method was developed for the determination of N-nitrosodiethanolamine (NDELA), which is a non-volatile N-nitrosoamine. In this method, sodium 1-octanesulfonate has been used as an ion complexation agent NDELA. The resulting complex analyzed by reversed-phase chromatography (RP-HPLC) using Eurospher-100 C18 column (250 x 4.6 mm, 5 microm), water/acetonitrile (95/5, v/v) and UV detection at 234 nm. detector response linear in range 0.03-10.00 microg mL(-1) limit 0.01 mL(-1). NDELA confirmed negative electrospray ionization mass spectrometry m/z 327 [M-Na](-) also MS/MS measurements fragments. For real sample analyses, measured cosmetic products after clean up solid-phase extraction (SPE) with C(18) cartridge water-soluble samples liquid-liquid (LLE) methylene chloride less samples. average values recovery SPE LLE were 86.9 51.8% relative standard deviations (RSDs%) 0.9 5.6%, respectively. presented easy to use, robust can be implemented on any HPLC system detection.
uni-bayreuth.de
elsevier.com参考文章(21)
Hardy J Chou, Determination of Diethanolamine and N-Nitrosodiethanolamine in Fatty Acid Diethanolamides Journal of AOAC International. ,vol. 81, pp. 943- 947 ,(1998) , 10.1093/JAOAC/81.5.943
Rolf Schwarzenbach, Joachim.P. Schmid, Determination of n-nitrosodiethanolamine in cosmetics : High-performance liquid chromatography and gas chromatography-mass spectrometry as alternative methods to chemiluminescence detection Journal of Chromatography A. ,vol. 472, pp. 231- 242 ,(1989) , 10.1016/S0021-9673(00)94109-8
Andrzej Kotyński, Zbigniew H. Kudzin, Application of trifluoroacetic anhydride-sodium iodide reagent for selective detection in thin-layer chromatography: IV. Thin-layer chromatographic differentiation of nitrones, nitroxide radicals and nitrosoamines in mixtures Journal of Chromatography A. ,vol. 663, pp. 127- 131 ,(1994) , 10.1016/0021-9673(94)80505-9
R. C. Schothorst, H. H. J. Somers, Determination of N-nitrosodiethanolamine in cosmetic products by LC-MS-MS Analytical and Bioanalytical Chemistry. ,vol. 381, pp. 681- 685 ,(2005) , 10.1007/S00216-004-2914-5
Remco Swart, Christian G. Huber, Hansjörg Toll, Herbert Oberacher, Separation, detection, and identification of peptides by ion-pair reversed-phase high-performance liquid chromatography-electrospray ionization mass spectrometry at high and low pH Journal of Chromatography A. ,vol. 1079, pp. 274- 286 ,(2005) , 10.1016/J.CHROMA.2005.03.121
Joseph A. Incavo, Melvin A. Schafer, Simplified method for the determination of N-nitrosamines in rubber vulcanizates Analytica Chimica Acta. ,vol. 557, pp. 256- 261 ,(2006) , 10.1016/J.ACA.2005.10.018
Stanley M. Billedeau, Thomas M. Heinze, Jon G. Wilkes, Harold C. Thompson, Application of the particle beam interface to high-performance liquid chromatography-thermal energy analysis and electron impact mass spectrometry for detection of non-volatile N-nitrosamines Journal of Chromatography A. ,vol. 688, pp. 55- 65 ,(1994) , 10.1016/0021-9673(94)00894-9
Maria T. Matyska, Joseph J. Pesek, Li Yang, Screening Method for Determining the Presence of N-nitrosodiethanolamine in Cosmetics by Open Tubular Capillary Electrochromatography Journal of Chromatography A. ,vol. 887, pp. 497- 503 ,(2000) , 10.1016/S0021-9673(00)00451-9
Richard N. Loeppky, Petra Goelzer, Microsome-mediated oxidation of N-nitrosodiethanolamine (NDELA), a bident carcinogen. Chemical Research in Toxicology. ,vol. 15, pp. 457- 469 ,(2002) , 10.1021/TX000267B
Cyrille A.M. Krul, Marco J. Zeilmaker, Ronald C. Schothorst, Robert Havenaar, Intragastric formation and modulation of N-nitrosodimethylamine in a dynamic in vitro gastrointestinal model under human physiological conditions Food and Chemical Toxicology. ,vol. 42, pp. 51- 63 ,(2004) , 10.1016/J.FCT.2003.08.005