Serum Glycopatterns as Novel Potential Biomarkers for Diagnosis of Acute-on-Chronic Hepatitis B Liver Failure

摘要: Acute-on-chronic hepatitis B liver failure (ACHBLF) is an increasingly recognized distinct disease entity encompassing acute deterioration of function in patients with cirrhosis, so little known about the alterations protein glycopatterns serum its development. We aimed to identify ACHBLF and probe possibility them as novel potential biomarkers for diagnosis ACHBLF. As a result, there were 18 lectins (e.g., WFA, GSL-II, PNA) give significantly compared healthy controls (HC) (all p ≤ 0.0386). Meanwhile, among these lectins, 12 GAL-II, EEL) also exhibited HBV-infected chronic (cHB) p ≤ 0.0252). The receiver-operating characteristic (ROC) curve analysis indicated 5 (PHA-E + L, BS-I, ECA, ACA, BPL) had greatest discriminatory power distinguishing HC or cHB, respectively p ≤ 0.00136). provided new basic insight into investigated correlation