ON pathway mutations increase susceptibility to form-deprivation myopia.

摘要: The ON pathway mutation in nob mice is associated with altered refractive development, and an increased susceptibility to form-deprivation (FD) myopia. In this study, we used mGluR6-/- mice, another mutant, determine whether the phenotype was due Nyx or abnormal transmission. Refractive development under a normal visual environment for age-matched wild-type (WT) measured every 2 weeks from 4 16 of age. response monocular FD age weekly separate cohort mice. Refraction ocular biometry were obtained using photorefractor optical coherence tomography. Retinas harvested at weeks, analyzed dopamine (DA) DOPAC high-performance liquid chromatography. Under conditions, significantly more myopic than their WT controls (refraction 12 weeks; WT: 9.40 ± 0.16 D, mGluR6-/-: 6.91 0.38 D). Similar two resulted significant shift -5.57 0.72 D compared -1.66 0.19 animals. No axial length changes observed either conditions. At retinas showed lower levels (111.2 33.0 pg/mg) counterparts (197.5 11.2 pg/mg). Retinal DA similar between different genotypes. Our results indicate that reduced retinal metabolism/turnover may be myopia defect mutations.