Diurnal metabolism of dopamine in the mouse retina.

摘要: Dopamine is an important retinal neurotransmitter and neuromodulator that regulates key diurnal cellular physiological functions. In the present study we carried out a comprehensive analysis of dopamine metabolism during light phase cycle evaluated presence circadian rhythms dopaminergic activity in mouse retina. Steady-state levels did not change significantly between dark (night) (day) cycle, nor they early late points day. synthesis utilization, however, revealed significant alterations night day time A spike utilization was measured immediately after onset at end night. Subsequently, partially declined remained stable throughout remainder level higher than The burst beginning entirely evoked driven by clock. Similarly, there no rhythm mice kept constant darkness. This daily pattern may impact upon variety temporally regulated events. Moreover, these data will provide basis for evaluating role pathology models degeneration where mutations affect perception.