Pro-senescence Therapy for Cancer: Time for the Clinic

摘要: Cellular senescence is a stable cell cycle arrest that occurs in diploid cells during aging. However, can also experience an accelerated response, termed pre-mature senescence, driven by DNA-damage, oncogene over-expression or loss of tumour suppressor genes. Recent evidences demonstrate cellular tumours, where it opposes initiation and progression. Senescence secrete variety cytokines secreted factors, known as the secretory phenotype (SASP), regulate both entry maintenance propagate to adjacent cells, acting non-autonomous manner. In addition, SASP promote recruitment activation immune turn mediate clearance senescent cancer cells.