Expression of P53 protein in primary uveal melanoma.

摘要: Malignant melanomas are the commonest intraocular tumours. The aim of present study was immunohistochemical analysis P53 protein expression in 39 primary ocular treated surgically years 1983-1997. Expression estimated semiquantitatively with use a light microscope at magnification x 400. At least 200 neoplastic cells per sample were analysed. 3% melanoma considered threshold positive reaction. results subjected to statistical exact Fischer's test. No statistically significant correlations found between and anatomoclinical properties tumours, although increased observed epithelioid-cellular tumours growing women. A lack relationship level parameters examined, morphological specificity hindering analysis, indicate necessity for studies on wider group or/and molecular biology techniques establish possible relations gene mutation biology.