Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma.

摘要: Background & Aims: Barrett's esophagus is a precursor of esophageal adenocarcinoma. DNA microarrays that enable genome-wide assessment gene expression enhance the identification specific genes as well patterns are expressed by and adenocarcinoma compared with normal tissues. length has also been identified risk factor for progression to adenocarcinoma, but whether there intrinsic biological differences between short-segment long-segment can be explored microarrays. Methods: Gene profiles endoscopically obtained biopsy specimens or associated duodenum were 17 patients using Unsupervised supervised approaches data analysis defined similarities tissues correlations clinical phenotypes. Results: Each tissue displays unique profile distinguishes it from others. express set stromal distinct similar other cancers. Adenocarcinoma showed lower higher many esophagus. No difference in was found Conclusions: The provided current reveals candidate not previously identified. Stromal similar, indicating these changes precede malignant transformation.