Clinical and serologic study of Sjögren's syndrome in patients with progressive systemic sclerosis.

摘要: Fifty-eight patients with progressive systemic sclerosis (PSS) were evaluated clinically and by biopsy of the minor salivary glands lips for presence Sjogren's syndrome. Clinical findings included dry eyes in 38%, mouth 32%, parotid enlargement 4%, an abnormal Schirmer's test 34%. Histologic changes lip biopsies lymphocytic infiltrates characteristic syndrome 17 individuals (29%). In 19 (33%) there was periglandular intraglandular fibrosis (PSS-fibrosis) without significant inflammation, alteration PSS per se. remaining 22 (38%) PSS, no abnormality found. Of those syndrome, 53% had serum antibodies to SS-A and/or SS-B, while only 1 patient a normal either these antibodies. Anti-SS-A anti-SS-B not detected glandular alone. The mortality rate PSS-fibrosis group higher due variety severe internal manifestations related PSS. Antibodies SS-B are useful serologic markers