Antibodies to cellular antigens in Sjögren's syndrome.

作者: M A Alspaugh , E M Tan

DOI: 10.1172/JCI108007

关键词:

摘要: An extract of human lymphocytes from continous cell culture was used as the antigen source to detect antibodies in sera patients with Sjogren's syndrome (SS). Using double diffusion agarose, 85 per cent a selected group had precepating antibodies. Three precipitating antigen-antibody systems were detected and shown be different those described previously othe systemic rheumatic diseases. The SS temporarily classified precipitins, A, B, C. patinets sicca but without clinical rheumatoid arthritis precipitin A and/or associated system Serum reactants demonstrated by immuno-electrophoresis migrate gamma globulin region. activity serum factors not destroyed treatment 2-mercaptoethanol removed absorption factor sera. reactivity lympuocyte antigens trypsin deoxyribonuclease or ribonuclease.

参考文章(25)
J. Williamson, W. W. Buchanan, A. C. A. Glen, W. C. Dick, G. Nuki, K. Whaley, R. N. M. MacSween, S. Deodhar, Immunological responses in Sjogren's syndrome and rheumatoid arthritis. Clinical and Experimental Immunology. ,vol. 9, pp. 721- ,(1971)
Tan Em, Relationship of nuclear staining patterns with precipitating antibodies in systemic lupus erythematosus. Journal of Laboratory and Clinical Medicine. ,vol. 70, pp. 800- 812 ,(1967)
H. G. Kunkel, E. M. Tan, Characteristics of a Soluble Nuclear Antigen Precipitating with Sera of Patients with Systemic Lupus Erythematosus Journal of Immunology. ,vol. 96, pp. 464- 471 ,(1966)
Morris Reichlin, Martha Mattioli, Characterization of a soluble nuclear ribonucleoprotein antigen reactive with SLE sera. Journal of Immunology. ,vol. 107, pp. 1281- 1290 ,(1971)
Y B Kim, S G Bradley, D W Watson, CHARACTERIZATION OF EARLY 19 S AND LATE 7 S IMMUNOGLOBULINS IN THE MOUSE. Journal of Immunology. ,vol. 93, pp. 798- 806 ,(1964)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
D. Koffler, V. Agnello, R. Thoburn, H. G. Kunkel, SYSTEMIC LUPUS ERYTHEMATOSUS: PROTOTYPE OF IMMUNE COMPLEX NEPHRITIS IN MAN Journal of Experimental Medicine. ,vol. 134, pp. 169- 179 ,(1971) , 10.1084/JEM.134.3.169
Brigid G. Leventhal, Donald S. Waldorf, Norman Talal, Impaired Lymphocyte Transformation and Delayed Hypersensitivity in Sjögren's Syndrome* Journal of Clinical Investigation. ,vol. 46, pp. 1338- 1345 ,(1967) , 10.1172/JCI105626
Norman Talal, Elias Zisman, Peter H. Schur, Renal tubular acidosis, glomerulonephritis and immunologic factors in Sjögren's syndrome. Arthritis & Rheumatism. ,vol. 11, pp. 774- 786 ,(1968) , 10.1002/ART.1780110607
J. S. Beck, J. R. Anderson, K. J. Bloch, W. W. Buchanan, J. J. Bunim, Antinuclear and Precipitating Auto-antibodies in Sjögren's Syndrome Annals of the Rheumatic Diseases. ,vol. 24, pp. 16- 22 ,(1965) , 10.1136/ARD.24.1.16