CHARACTERIZATION OF EARLY 19 S AND LATE 7 S IMMUNOGLOBULINS IN THE MOUSE.

摘要: Summary Biphasic responses and differing rates of neutralizing activity early late sera from BALB/Sy mice given single multiple injections actinophage indicated two types antibodies in phage neutralization. By the use physical immunochemical techniques serum was found to be associated with a γ 1 -immunoglobulin 19 S class. The contained mostly 2 7 antibody inactivated by 2-mercaptoethanol contrast stability antibodies. Immunoelectrophoretic patterns pooled mouse were typical rabbit human patterns. In mouse, however, mercaptoethanol dissociates so-called β M into new component mobility of, but antigenically distinct from, -immunoglobulin. immunoglobulin is not related classical line fast -globulin appears identical. implication apparent close relationship these classes discussed relation mechanism their production.