Application of plasminogen polymorphism to forensic hemogenetics.
作者： Ulrike Skoda , Anne Klein , Ingeborg Lübcke , Gottfried Mauff , Gerhard Pulverer
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摘要: Plasminogen polymorphism (PLG) has attained considerable importance in forensic hemogenetics. PLG comprises two common, codominant autosomal alleles, PLG*A and PLG*B, more than 18 variants, the silent allele PLG*Q0. Isoelectric focusing followed by functional or immunochemical detection seems to be optimal method for determination of phenotypes. is most common all populations, having its highest frequency Mongoloids, Amerindians Eskimos, lowest Caucasoids. The functionally inactive plasminogen M5 so far been seen exclusively Japanese individuals. Silent alleles were only observed heterozygous state. No clear differences activity plasma level could ascertained any other allotypes. now widely used many haemogenetic investigations. From distribution European Caucasoids a single exclusion chance 17.2% non-fathers paternity testing may calculated. major prerequisites new genetic marker parentage expertise, established Mendelian inheritance, favorable low simple reproducible typing technology, are fulfilled.
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