Stress in utero alters neonatal stress-induced regulation of the synaptic plasticity proteins Arc and Egr1 in a sex-specific manner.

摘要: The present study in juvenile rats investigated a "two-hit model" to test the impact of prenatal stress exposure ("first hit") on regulation synaptic plasticity immediate early genes Arc and Egr1 response second neonatal stressor ("second sex-specific manner. Three stress-exposed animal groups were compared at age 21 days relation unstressed controls (CON): preS animals exposed various unpredictable stressors during last gestational trimester; postS 45 min restraint postnatal day 21, pre/postS combination pre- as described for two previous groups. killed 2 h after stressor, males females separately analyzed. In line with our hypothesis we detected sensitivity both analyzed proteins. Males did not show any significant changes expression irrespective condition. contrast, females, which had been pre-exposed stress, displayed an "amplified" upregulation (pre/postS group) controls, may reflect "sensitization" effect stress. For Egr1, stress-induced condition, whereas males, observed "protective" downregulation group), indicate that induce "resilience".