Early-life environmental intervention may increase the number of neurons, astrocytes, and cellular proliferation in the hippocampus of rats.
作者： Elisa C. Winkelmann-Duarte , Camila B. Padilha-Hoffmann , Daniel F. Martins , Artur F. S. Schuh , Marilda C. Fernandes
DOI: 10.1007/S00221-011-2881-Y
关键词:
摘要: Neonatal handling reduces the stress response in adulthood due to a feedback mechanism. The present study analyzed effects of repeated neonatal environmental intervention (daily during first 10 days after birth) on neuron-, astroglial cell density, and cellular proliferation hippocampal (CA1, CA2, CA3) pyramidal layers female rats. Pups were divided into two groups, nonhandled handled, which submitted sessions between postnatal 1 10. Histological immunohistochemical procedures used determine changes neuron proliferation. We found an increase density each layer hippocampus rats (11 90 day old) that handled period. Furthermore, we both hemispheres brain group. Finally, observed hippocampi pups This demonstrates early-life may induce morphological structure involved with several functions, including response. results current suggest influence animals’ responses adversities later life.
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