Regulatory Considerations in Vaccine Design

摘要: Vaccines, both those now approved and that are in development, represent a variety of technologies, as shown Table I. Earlier vaccines were preparations killed, or inactivated, bacterial cells viruses. Other early toxoids. Often, it was not known why vaccine worked, only did. As knowledge disease, immunology, protection increased, became more sophisticated. Advances technology led to consisted purified viral antigens, live, attenuated vaccines. Conjugate allows poorly immunogenic antigen be coupled highly carrier molecule. Recombinant an isolated produced without the involvement pathogenic organism. Examples development illustrate various technologies used produce today’s also