Scientific and social issues of human immunodeficiency virus vaccine development

作者: B. Haynes

DOI: 10.1126/SCIENCE.8493572

关键词:

摘要: Development of a preventive immunogen for human immunodeficiency virus (HIV) infection is national priority. The complexities associated with HIV host-virus interactions, coupled the rapid progression epidemic worldwide, have necessitated lowering expectations an vaccine that 100 percent effective and raised important scientific nonscientific issues regarding development use therapeutic vaccines.

参考文章(78)
T. C. McGuire, D. S. Adams, G. C. Johnson, D. D. Barbee, J. R. Gorham, P. Klevjer-Anderson, Acute arthritis in caprine arthritis-encephalitis virus challenge exposure of vaccinated or persistently infected goats. American Journal of Veterinary Research. ,vol. 47, pp. 537- 540 ,(1986)
L. Griffin, E.W. Allonby, J.M. Preston, The interaction of Trypanosoma congolense and Haemonchus contortus infections in 2 breeds of goat. 1. Parasitology. Journal of Comparative Pathology. ,vol. 91, pp. 85- 95 ,(1981) , 10.1016/0021-9975(81)90048-7
W E Robinson, T Kawamura, D Lake, Y Masuho, W M Mitchell, E M Hersh, Antibodies to the primary immunodominant domain of human immunodeficiency virus type 1 (HIV-1) glycoprotein gp41 enhance HIV-1 infection in vitro Journal of Virology. ,vol. 64, pp. 5301- 5305 ,(1990) , 10.1128/JVI.64.11.5301-5305.1990
N L Haigwood, P L Nara, E Brooks, G A Van Nest, G Ott, K W Higgins, N Dunlop, C J Scandella, J W Eichberg, K S Steimer, Native but not denatured recombinant human immunodeficiency virus type 1 gp120 generates broad-spectrum neutralizing antibodies in baboons. Journal of Virology. ,vol. 66, pp. 172- 182 ,(1992) , 10.1128/JVI.66.1.172-182.1992
D D Ho, M G Sarngadharan, M S Hirsch, R T Schooley, T R Rota, R C Kennedy, T C Chanh, V L Sato, Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins. Journal of Virology. ,vol. 61, pp. 2024- 2028 ,(1987) , 10.1128/JVI.61.6.2024-2028.1987
R M Scearce, A J Langlois, B F Haynes, D P Bolognesi, M K Hart, M E Martin, N W Lerche, T J Palker, C McDanal, T J Matthews, Synthetic peptides containing T and B cell epitopes from human immunodeficiency virus envelope gp120 induce anti-HIV proliferative responses and high titers of neutralizing antibodies in rhesus monkeys. Journal of Immunology. ,vol. 145, pp. 2677- 2685 ,(1990)
J Salk, P. Bretscher, P. Salk, M Clerici, G. Shearer, A strategy for prophylactic vaccination against HIV Science. ,vol. 260, pp. 1270- 1272 ,(1993) , 10.1126/SCIENCE.8098553
David E. Rogers, June E. Osborn, Another Approach to the AIDS Epidemic New England Journal of Medicine. ,vol. 325, pp. 806- 808 ,(1991) , 10.1056/NEJM199109123251111
J Cohen, Dingell rips Healy for 'obstructionism'. Science. ,vol. 258, pp. 1729- 1729 ,(1992) , 10.1126/SCIENCE.1465608
H Golding, G M Shearer, K Hillman, P Lucas, J Manischewitz, R A Zajac, M Clerici, R E Gress, R N Boswell, B Golding, Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals. Journal of Clinical Investigation. ,vol. 83, pp. 1430- 1435 ,(1989) , 10.1172/JCI114034